There are many ways to reach the island of Leros.
One of the most comfortable ways to reach Leros is by the catamaran of Dodekanisos Seaways. It sails from Kos and Rhodes, every day in high season. Read more about this catamaran here.
You can also reach Leros by hydrofoil boat the Flying Dolphin, from the islands Kos and Samos. Check it out at aegeanflyingdolphins.gr
You can also choose for the Bluestar ferry from the port of Piraeus (close to Athens).
Leros can also be reached by air from Athens by Olympic Air.
Handy links for travel
Greek Travel Pages: 30.000 sea schedules within Greece, to/from Greece, port authorities, how to book options and much more.
Trips to and from Kalymnos and Kos, Mastachari airport. Available in greek and English language, click here for the website.